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- What Bunnie Xo experienced after taking a GLP-1 drug
- Why she turned to a GLP-1: family history and health concerns
- How she described the mental toll and recovery
- What experts and patients should consider about GLP-1 side effects
- Practical steps for people considering GLP-1 medications
- Resources for crisis help and support
Bunnie Xo, the podcast host married to country star Jelly Roll, says a popular GLP-1 medication triggered an alarming and unexpected mental health crisis late last year. In a candid interview with PEOPLE, she described vivid suicidal thoughts that surprised her and pushed her into one of the darkest periods she’s faced.
What Bunnie Xo experienced after taking a GLP-1 drug
According to Bunnie, the episode began in December 2025 after she started using a GLP-1 medication. She had expected benefits for blood sugar and weight, but instead says she was overwhelmed by intense suicidal ideation. The feelings were new to her and unlike the anxiety she had previously managed.
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- Sudden onset of persistent, dark thoughts
- Vivid mental images and a pervasive sense of despair
- Contrast with prior anxiety-only symptoms
Why she turned to a GLP-1: family history and health concerns
Bunnie explained that diabetes runs in her family, and she hoped the medication would help control her insulin levels. She said her glucose readings were erratic and that she believed a GLP-1 could be a healthful step. Instead, her body reacted negatively.
Health goals vs. unexpected risks
Many people try GLP-1 drugs for weight loss or to manage type 2 diabetes. Bunnie’s experience underscores that even when taken for legitimate medical reasons, side effects can be profound and unpredictable.
How she described the mental toll and recovery
Bunnie recalled being stunned by how profound the thoughts were. She had not felt suicidal since 2020 and found the recurrence terrifying. She told the outlet that December was especially rough, though she says she is doing better now.
- Immediate recognition of danger and fear
- Seeking support and emphasizing recovery
- Recommending open conversations about side effects
Her message to others struggling
She urged anyone facing similar darkness to stay and seek help. Her plea was simple and direct: emotions pass, and acting on a fleeting crisis can lead to permanent tragedy. She emphasized that people are not alone in their struggles.
What experts and patients should consider about GLP-1 side effects
GLP-1 agonists have become widely discussed for weight loss and diabetes care. While many tolerate these drugs well, there are reports of mood changes and rare but serious psychiatric effects. Bunnie’s account adds to calls for clearer labeling and wider public discussion.
- Discuss family and personal psychiatric history with a prescriber.
- Monitor mood changes closely in the weeks after starting therapy.
- Report any suicidal thoughts immediately to a healthcare professional.
Practical steps for people considering GLP-1 medications
Patients and providers can take simple precautions to reduce risk and catch problems early:
- Ask about mental health side effects before beginning treatment.
- Set up regular check-ins during the first months.
- Have a safety plan and emergency contacts ready.
Resources for crisis help and support
If you or someone you know is in crisis, call or text 988 to reach the Suicide & Crisis Lifeline. The previous Lifeline number, 1-800-273-8255, remains available.
Seeking immediate medical attention is vital if suicidal thoughts arise after starting any new medication. Pharmacists and prescribers can help weigh risks and alternatives. Friends and family can provide vital support by listening and helping connect someone to care.
